Online courses directory (117)
Numerical methods for solving problems arising in heat and mass transfer, fluid mechanics, chemical reaction engineering, and molecular simulation. Topics: numerical linear algebra, solution of nonlinear algebraic equations and ordinary differential equations, solution of partial differential equations (e.g. Navier-Stokes), numerical methods in molecular simulation (dynamics, geometry optimization). All methods are presented within the context of chemical engineering problems. Familiarity with structured programming is assumed. The examples will use MATLAB®.
Acknowledgements
The instructor would like to thank Robert Ashcraft, Sandeep Sharma, David Weingeist, and Nikolay Zaborenko for their work in preparing materials for this course site.
This course introduces abstraction as an important mechanism for problem decomposition and solution formulation in the biomedical domain, and examines computer representation, storage, retrieval, and manipulation of biomedical data. As part of the course, we will briefly examine the effect of programming paradigm choice on problem-solving approaches, and introduce data structures and algorithms. We will also examine knowledge representation schemes for capturing biomedical domain complexity and principles of data modeling for efficient storage and retrieval. The final project involves building a medical information system that encompasses the different concepts taught in the course.
Computer science basics covered in the first part of the course are integral to understanding topics covered in the latter part, and for completing the assigned homework.
This course begins with a study of the role of dynamics in the general physics of the atmosphere, the consideration of the differences between modeling and approximation, and the observed large-scale phenomenology of the atmosphere. Only then are the basic equations derived in rigorous manner. The equations are then applied to important problems and methodologies in meteorology and climate, with discussions of the history of the topics where appropriate. Problems include the Hadley circulation and its role in the general circulation, atmospheric waves including gravity and Rossby waves and their interaction with the mean flow, with specific applications to the stratospheric quasi-biennial oscillation, tides, the super-rotation of Venus' atmosphere, the generation of atmospheric turbulence, and stationary waves among other problems. The quasi-geostrophic approximation is derived, and the resulting equations are used to examine the hydrodynamic stability of the circulation with applications ranging from convective adjustment to climate.
The course provides students with (1) an introduction to the geologic history of western North America, with particular emphasis on our field camp location and (2) an introduction to both digital and traditional techniques of geological field study. The weather permitting, several weekend field exercises provide practical experience in preparation for Field Geology II (12.115). It presents introductory material on the regional geology of the locale of 12.115.
The introductory topics will cover various approaches to the study of animals and their behavior. Key concepts in studies of animal behavior, emphasizing ethology, are covered in class and in the assigned readings from Scott (2005), supplemented by selections from other books, especially from classics in the field as well as selected videos. Next, key concepts in sociobiology are covered using readings from Alcock (2001), supplemented by selections from additional books and some video presentations.
Life as an emergent property of networks of chemical reactions involving proteins and nucleic acids. Mathematical theories of metabolism, gene regulation, signal transduction, chemotaxis, excitability, motility, mitosis, development, and immunity. Applications to directed molecular evolution, DNA computing, and metabolic and genetic engineering.
This course is designed to provide an understanding of how the human brain works in health and disease, and is intended for both the Brain and Cognitive Sciences major and the non-Brain and Cognitive Sciences major. Knowledge of how the human brain works is important for all citizens, and the lessons to be learned have enormous implications for public policy makers and educators.
The course will cover the regional anatomy of the brain and provide an introduction to the cellular function of neurons, synapses and neurotransmitters. Commonly used drugs that alter brain function can be understood through a knowledge of neurotransmitters. Along similar lines, common diseases that illustrate normal brain function will be discussed. Experimental animal studies that reveal how the brain works will be reviewed.
Throughout the seminar we will discuss clinical cases from Dr. Byrne's experience that illustrate brain function; in addition, articles from the scientific literature will be discussed in each class.
Introduction to the linguistic study of language pathology, concentrating on experimental approaches and theoretical explanations. Discussion of Specific Language Impairment, autism, Down syndrome, Williams syndrome, normal aging, Parkinson's disease, Alzheimer's disease, hemispherectomy and aphasia. Focuses on the comparison of linguistic abilities among these syndromes, while drawing clear comparisons with first and second language acquisition. Topics include the lexicon, morphology, syntax, semantics and pragmatics. Relates the lost linguistic abilities in these syndromes to properties of the brain.
The course includes survey and special topics designed for graduate students in the brain and cognitive sciences. It emphasizes ethological studies of natural behavior patterns and their analysis in laboratory work, with contributions from field biology (mammology, primatology), sociobiology, and comparative psychology. It stresses mammalian behavior but also includes major contributions from studies of other vertebrates and of invertebrates. It covers some applications of animal-behavior knowledge to neuropsychology and behavioral pharmacology.
This course studies the relations of affect to cognition and behavior, feeling to thinking and acting, and values to beliefs and practices. These connections will be considered at the psychological level of organization and in terms of their neurobiological and sociocultural counterparts.
This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. We focus on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); we also examine amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems and ion fluxes that they control. The involvement of particular neurotransmitters in human diseases is considered.
This course serves as an introduction to the structure and function of the nervous system. Emphasis is placed on the cellular properties of neurons and other excitable cells. Topics covered include the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, and the integration of information in simple systems and the visual system.
This course considers molecular control of neural specification, formation of neuronal connections, construction of neural systems, and the contributions of experience to shaping brain structure and function. Topics include: neural induction and pattern formation, cell lineage and fate determination, neuronal migration, axon guidance, synapse formation and stabilization, activity-dependent development and critical periods, development of behavior.
Consists of a series of hands-on laboratories designed to give students experience with common techniques for conducting neuroscience research. Included are sessions on anatomical, ablation, neurophysiological, and computer modeling techniques, and ways these techniques are used to study brain function. Each session consists of a brief quiz on assigned readings that provide background to the lab, a lecture that expands on the readings, and that week's laboratory. Lab reports required. Students receive training in the art of scientific writing and oral presentation with feedback designed to improve writing and speaking skills. Assignments include two smaller lab reports, one major lab report with revision, and an oral report.
This course provides an outline of vertebrate functional neuroanatomy, aided by studies of comparative neuroanatomy and evolution, and by studies of brain development. Topics include early steps to a central nervous system, basic patterns of brain and spinal cord connections, regional development and differentiation, regeneration, motor and sensory pathways and structures, systems underlying motivations, innate action patterns, formation of habits, and various cognitive functions. In addition, lab techniques are reviewed and students perform brain dissections.
This course explores the major areas of cellular and molecular neurobiology, including excitable cells and membranes, ion channels and receptors, synaptic transmission, cell-type determination, axon guidance, neuronal cell biology, neurotrophin signaling and cell survival, synapse formation and neural plasticity. Material includes lectures and exams, and involves presentation and discussion of primary literature. It focuses on major concepts and recent advances in experimental neuroscience.
This course includes:
- Surveying the molecular and cellular mechanisms of neuronal communication.
- Coversion channels in excitable membrane, synaptic transmission, and synaptic plasticity.
- Correlation of the properties of ion channels and synaptic transmission with their physiological function such as learning and memory.
- Discussion of the organizational principles for the formation of functional neural networks at synaptic and cellular levels.