Courses tagged with "Diencephalon" (58)

5.451 is a half-semester introduction to natural product biosynthetic pathways. The course covers the assembly of complex polyketide, peptide, terpene and alkaloid structures. Discussion topics include chemical and biochemical strategies used to elucidate natural product pathways.

The course, which spans two thirds of a semester, provides students with a research-inspired laboratory experience that introduces standard biochemical techniques in the context of investigating a current and exciting research topic, acquired resistance to the cancer drug Gleevec. Techniques include protein expression, purification, and gel analysis, PCR, site-directed mutagenesis, kinase activity assays, and protein structure viewing.

This class is part of the new laboratory curriculum in the MIT Department of Chemistry. Undergraduate Research-Inspired Experimental Chemistry Alternatives (URIECA) introduces students to cutting edge research topics in a modular format.

Acknowledgments

Development of this course was funded through an HHMI Professors grant to Professor Catherine L. Drennan.

This is a continuation of Freshman Organic Chemistry I (CHEM 125a), the introductory course on current theories of structure and mechanism in organic chemistry for students with excellent preparation in chemistry and physics. This semester treats simple and complex reaction mechanisms, spectroscopy, organic synthesis, and some molecules of nature.

The focus of this guided inquiry laboratory is to foster critical thinking that allows students to design, perform, and interpret experiments. In addition, the student acquires technical skills that are required for further advancement in experimental sciences. Although an ability to collect and analyze data in a quantitative manner is developed, the emphasis of the course is to provide a qualitative understanding of the basic concepts of chemistry. This is accomplished by demonstrating that chemical principles are derived from experimental data. The goal is to provide students both with a more accurate picture of the scientific process and with skills that are relevant to solving real life problems. Course Level: Undergraduate This Work, Chemistry 125/126 - General Chemistry Laboratory 1, by Nancy Kerner is licensed under a Creative Commons Attribution-ShareAlike license.

Physical Chemistry II is quite different from Physical Chemistry I.  In this second semester of the Physical Chemistry course, you will study the principles and laws of quantum mechanics as well as the interaction between matter and electromagnetic waves.  During the late 19th century and early 20th century, scientists opened new frontiers in the understanding of matter at the molecular, atomic, and sub-atomic scale.  These studies resulted in the development of quantum physics, which nowadays is still considered one of the greatest achievements of human mind.  While present day quantum physics “zooms in” to look at subatomic particles, quantum chemistry “zooms out” to look at large molecular systems in order to theoretically understand their physical and chemical properties.  Quantum chemistry has created certain “tools” (or computational methods) based on the laws of quantum mechanics that make it theoretically possible to understand how electrons and atomic nuclei interact with each other…

This course is the second installment of Single-Variable Calculus.  In Part I (MA101) [1], we studied limits, derivatives, and basic integrals as a means to understand the behavior of functions.  In this course (Part II), we will extend our differentiation and integration abilities and apply the techniques we have learned. Additional integration techniques, in particular, are a major part of the course.  In Part I, we learned how to integrate by various formulas and by reversing the chain rule through the technique of substitution.  In Part II, we will learn some clever uses of substitution, how to reverse the product rule for differentiation through a technique called integration by parts, and how to rewrite trigonometric and rational integrands that look impossible into simpler forms.  Series, while a major topic in their own right, also serve to extend our integration reach: they culminate in an application that lets you integrate almost any function you’d like. Integration allows us to calculat…

Advanced Inorganic Chemistry is designed to give you the knowledge to explain everyday phenomena of inorganic complexes. You will study the various aspects of their physical and chemical properties and learn how to determine the practical applications that these complexes can have in industrial, analytical, and medicinal chemistry. This course will begin with the discussion of symmetry and point group theory and its applications in the field of vibrational spectroscopy. We will then study molecular orbital (MO) theory specifically applied to metal organic complexes. MO theory will be critical in understanding the following: 1) the relative position of ligands in the spectrochemical series, 2) the electronic transitions and related selection rules, and 3) the application of spectroscopy of metals. The course will then move onto the study of the oxidation states of transition metals and their redox properties. A firm grasp of the chemical redox properties of transition metals is critical to understanding thei…

Inorganic chemistry is a division of chemistry that studies metals, their compounds, and their reactivity.  Metal atoms can be bound to other metal atoms in alloys or metal clusters, to nonmetal elements in crystalline rocks, or to small organic molecules, such as a cyclopentadienyl anion in ferrocene.  These metal atoms can also be part of large biological molecules, as in the case of iron in hemoglobin (oxygen-carrier protein in the blood). In this course, you should not think of metals as you encounter them in your daily life (i.e., when you pick up a steel knife, a can of soda, or a gold necklace).  Instead, you should think of a metal as the central atom or ion in a molecule surrounded by other ions or small molecules called ligands.  Depending on what these ligands are, the metal-containing compound can acquire very different physical and chemical properties.  For example, when magnesium (in its ionic state) is bound to carbonate ions, it forms solid crystalline rocks, as in the dolomite rocks (c…

This course is a continuation of CHEM103 [1]: Organic Chemistry I.  As you progress through the units below, you will continue to learn the different chemical reactions characteristic of each family of organic compounds.  We will focus on the four most important classes of reactions: electrophilic substitution at aromatic rings, nucleophilic addition at carbonyl compounds, hydrolysis of carboxylic acids, and carbon-carbon bond formation using enolates.  The enolate portion of this course will cover the reactivity of functional groups. We will also look at synthetic strategies for making simple, small organic molecules, using the knowledge of organic chemistry accumulated thus far.  At the end of this course, you will possess the tools you need to plan the synthesis of fairly complicated molecules, like those used in pharmaceutics.  From the perspective of a synthetic organic chemist, the two most challenging aspects of synthesizing drug molecules are the incorporation of  "molecular rings" (rings of 5…

This chemistry survey is designed to introduce students to the world of chemistry.  The principles of chemistry were first identified, studied, and applied by ancient Egyptians in order to extract metal from ores, make alcoholic beverages, glaze pottery, turn fat into soap, and much more.  What began as a quest to build better weapons or create potions capable of ensuring everlasting life has since become the foundation of modern science.  Take a look around you: chemistry makes up almost everything you touch, see, and feel, from the shampoo you used this morning to the plastic container that holds your lunch.  In this course, we will study chemistry from the ground up, learning the basics of the atom and its behavior.  We will use this knowledge to understand the chemical properties of matter and the changes and reactions that take place in all types of matter.

Spectroscopy is the study of the interaction between matter and electromagnetic radiation.  Molecules respond to different types of radiation in different ways, depending on the frequency (?) or wavelength (?) of the radiation.  In General Chemistry, we studied spectroscopy as a tool for explaining the quantum mechanical model of the atom.  In that course, we learned that light is an electromagnetic radiation of a wavelength that is visible to the human eye.  We also learned that light, which exists in tiny “packets” called photons, exhibits properties of both waves and particles, a characteristic referred to as the wave-particle duality.  The quantized relationship is defined as E = hv, where E is energy, h is Plank’s constant, and v is frequency. Spectroscopy and spectrometry are often used in chemistry for the identification of substances through the spectrum from which they are emitted or by which they are absorbed.  The type of spectroscopic technique is defined by the type of radia…

Organic chemistry is a branch of chemistry that focuses on a single element: carbon!  Carbon bonds strongly with other carbon atoms and with other elements, forming numerous chain and ring structures.  As a result, there are millions of distinct carbon compounds known and classified.  The vast majority of the molecules that contain carbon are considered organic molecules, with few debatable exceptions such as carbon nanotubes, diamonds, carbonate ions, and carbon dioxide.  Carbon is central to the existence of life as it is an essential component of nucleic acids (DNA and RNA), sugars, lipids, and proteins.  A well-rounded student of science must take courses in organic chemistry to understand its application to various topics, such as the study of polymers (plastics and other materials), hydrocarbons, pharmaceuticals, molecular biology, biochemistry, and other life sciences. In the first semester of organic chemistry, you will learn the basic concepts needed to understand the three-dimensional structu…

Analytical chemistry is the branch of chemistry dealing with measurement, both qualitative and quantitative.  This discipline is also concerned with the chemical composition of samples.  In the field, analytical chemistry is applied when detecting the presence and determining the quantities of chemical compounds, such as lead in water samples or arsenic in tissue samples.  It also encompasses many different spectrochemical techniques, all of which are used under various experimental conditions.  This branch of chemistry teaches the general theories behind the use of each instrument as well analysis of experimental data. This course begins with a review of general chemistry and an introduction to analytical terminology.  You will learn terms relevant to the process of measuring chemical compounds, such as sensitivity and detection limit.  The course continues with a unit on common spectrochemical methods, followed by an extension of these methods in a unit on atomic spectroscopy.  These methods allow…

Organic Chemistry of Macromolecules covers the preparation, reactions, and properties of high molecular weight polymeric materials of both natural and synthetic origin. As a part of this course, U-M students collaboratively created and edited Wikipedia articles. Course Level: Graduate This Work, Chemistry 538 - Organic Chemistry of Macromolecules, by Anne McNeil is licensed under a Creative Commons Attribution-ShareAlike license.

In this second semester course, we will cover a wide-ranging field of topics, learning everything from the equation that made Einstein famous to why you can’t replace a dead car battery with a household battery. In General Chemistry I (CHEM101 [1]), we studied the basic tools you need to explore different fields in chemistry, such as stoichiometry and thermodynamics.  This second-semester course will cover several of the tools needed to study chemistry at a more advanced level.  We will identify the factors that affect the speed of a reaction, learn how an atom bomb works on a chemical level, and discover how chemistry powers a light bulb.  Topics in advanced organic and inorganic chemistry courses will build upon what you learn in this class.  We will end with discussion of organic chemistry, a topic that is as important to biology as it is to chemistry. [1] http:///courses/chem101/…

Biochemistry is the study of the chemical processes and compounds, such as cellular makeup, that bring about life in organisms.  It is a combination of multiple science fields; you can think of it as general and cell biology coupled with organic and general chemistry.  Although living organisms are very complex, from a molecular view, the material that constitutes “life” can be broken down into remarkably simple molecules, much like the breakdown of our English language to the English alphabet.  Although there exists thousands upon thousands of molecules, they all breakdown into four core components: nucleic acids, amino acids, lipids, and carbohydrates.  As we can make hundreds of thousands of words from just 26 letters, we can make thousands of different biomolecules from those 4 components.  For example, the human genome, containing the necessary information to create a human being, is really just one very long strand of 4 different nucleotides. This course is structured around that approach, so…

Remember that organic chemistry is the discipline that studies the properties and reactions of organic, carbon-based compounds.  This course is intended to be taken after the first two semesters of organic chemistry.  Many of the topics within this outline have been covered in the first two semesters of organic chemistry; however, this course will explore these topics in much greater depth.  It is important to make sure that you have a good grasp of the concepts from earlier organic chemistry courses before moving on to this course. We begin by studying a unit on ylides, benzyne, and free radicals.  Many free radicals affect life processes.  For example, oxygen-derived radicals may be overproduced in cells, such as white blood cells that try to defend against infection in a living organism.  In the first unit, you will learn about free radicals, including oxygen-containing compounds.  Afterward we move into a comprehensive examination of stereochemistry, as well as the kinetics of substitution and el…

This course is designed to introduce you to the study of Calculus.  You will learn concrete applications of how calculus is used and, more importantly, why it works.  Calculus is not a new discipline; it has been around since the days of Archimedes.  However, Isaac Newton and Gottfried Leibniz, two 17th-century European mathematicians concurrently working on the same intellectual discovery hundreds of miles apart, were responsible for developing the field as we know it today.  This brings us to our first question, what is today's Calculus?  In its simplest terms, calculus is the study of functions, rates of change, and continuity.  While you may have cultivated a basic understanding of functions in previous math courses, in this course you will come to a more advanced understanding of their complexity, learning to take a closer look at their behaviors and nuances. In this course, we will address three major topics: limits, derivatives, and integrals, as well as study their respective foundations and a…